Sr./Clinical Trial Manager

Responsibilities

Support the development, maintenance, and execution on detailed study operational plans, timelines, enrollment projections, and tracking tools in alignment with program strategy and Director guidance

Responsible for vendor oversight activities, for assigned vendors, including deliverables, performance metrics, issue resolution, meeting governance, invoices, and scope tracking; supports vendor selection and Scope of Work development

Maintain clinical trial budgets and forecasts; review invoices, track committed and actual spend, identify variances, and escalate financial risks to the Director

Maintain study risk, issue, decision, and action logs; drives mitigation and resolution activities and promptly escalates material risks with recommended options

Coordinate operational input into the development, review, and implementation of clinical documents, including protocols, monitoring plans, informed consent forms, investigator brochures, pharmacy and laboratory manuals, and clinical study reports

Oversee global or regional study start-up, site activation, enrollment, conduct, monitoring, closeout, and inspection-readiness activities for assigned trials

Support planning and conducting investigator meetings in alignment with Director guidance

Responsible for monitoring oversight, inclusive of study specific templates and plans, reviewing monitoring reports for compliance to study protocols, regulations and ICF/GCP, tracking and managing monitoring report metrics

Build effective working relationships with clinical sites, investigators, CROs, vendors, and internal stakeholders and serves as a key operational point of contact

Review study performance metrics and operational data, identifies trends or gaps, and implements corrective and preventive actions in partnership with the Director and cross-functional team

Ensure clinical trial activities and documentation comply with the protocol, Good Clinical Practice, applicable regulations, contractual requirements, and company procedures

Support clinical supply, central laboratory, data management, safety, biostatistics, medical monitoring, and regulatory activities by coordinating operational requirements and timelines

Oversee the maintenance of a complete, accurate, and inspection-ready Trial Master File documentation and supports audits, inspections, and quality oversight activities

Mentor Clinical Trial Associates and Clinical Trial Managers; contributes to Clinical Operations process improvements, and prepare clear study updates for governance and senior leadership

Preferred

global clinical trial experience is preferred

Immunology and/or rare disease clinical trial experience is preferred

Experience mentoring or providing day-to-day guidance to junior team members is preferred

experience at a small startup is a plus

Benefits

This is a remote role

Clinical-stage developer of autoimmune disease therapies.

Waltham, Massachusetts, USA

https://jadebiosciences.com

Public Company

Total Funding

$725M

Key Investors

Fairmount Funds Management,Venrock

2026-06-03

Post Ipo Equity· $150M

2025-12-16

Post Ipo Equity· $45M

2025-10-07

Post Ipo Equity· $135M

Leadership Team

Tom Frohlich

Chief Executive Officer

Brad Dahms

Chief Financial Officer

Recent News

BioSpace

Jade Biosciences Announces Preclinical Data Characterizing JADE301, a Potentially Best-in-Class, Half-Life-Extended Anti-IFN-β Monoclonal Antibody in Development for Dermatomyositis, at EADV 2026

2026-09-30

Jade Biosciences Reports Second Quarter 2026 Financial Results and Provides Corporate Update

2026-08-10

citybiz

Jade Biosciences Appoints Dr. Mark Eisner to Board of Directors

2026-08-06

Company data provided by

Qualifications

Bachelors and10+ years of related experience for Sr Clinical Trial Manager and 7+ years of related experience for the Clinical Trial Manager

Trial management within a biopharmaceutical company

Demonstrated ability to manage complex clinical trial activities, timelines, vendors, budgets, risks, and cross-functional deliverables with appropriate independence and escalation

Experience supporting Phase 1 through Phase 3 clinical trials

Experience managing CROs and clinical vendors, including laboratories, RTSM, EDC, and ancillary clinical technology or applications

Strong working knowledge of FDA regulations, ICH guidelines, Good Clinical Practice, medical terminology, and clinical trial conduct

Working knowledge of clinical protocol implementation, regulatory submissions, Trial Master File requirements, and the overall drug development process

Excellent communication, organization, collaboration, problem-solving, and attention-to-detail skills, with the ability to manage competing priorities

Global clinical trial experience is preferred

Immunology and/or rare disease clinical trial experience is preferred

Experience mentoring or providing day-to-day guidance to junior team members is preferred

Experience at a small startup is a plus

Required skills

Clinical Trial Management, Biopharmaceutical Clinical Trials, Phase 1–3 Clinical Trials, Immunology Clinical Trials, CRO and Clinical Vendor Management, RTSM, Electronic Data Capture (EDC), FDA Regulations, ICH Guidelines, Clinical Practice (GCP), Clinical Protocol Implementation, Regulatory Submissions, Trial Master File (TMF) Management

Preferred skills

global clinical trial experience is preferred, experience at a small startup is a plus

Experience

7+ years